March 2019, Yoni lectures in Shderot.
March 2019, Yoni lectures in Shderot.








Publications
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Inbar, D., Kupchik M.Y., Ben-Zvi, D., Yovel, Y., Sadeh, I., (2024) Engaging high-school students in scientific conferences. Trends Ecol Evol. Jun:39(6):507-509. doi: 10.1016/j.tree.2024.03.007.
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Bernat, N., Campbell, R.R., Nam, H., Basu, M., Odesser, T., Elyasaf, G., Engeln, M., Chandra, R., Golden, S., Ament, S., Lobo M.K., Kupchik, Y.M. (2024) Multimodal interogation of ventral pallidum projections reveals projection-specific signatures and effects on cocaine reward. J Neurosci. May 1: 44(18): e1469232024. doi: 10.1523/JNEUROSCI.1469-23.2024.
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Inbar K,, Levi LA,, Kupchik Y.M. (2022) Cocaine induces input and cell-type-specific synaptic plasticity in ventral pallidum-projecting nucleus accumbens medium spiny neurons. Neuropsychopharmacology. Jul;47(8):1461-1472. doi: 10.1038/s41386-022-01285-6.
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Kupchik YM,, Prasad AA (2021) Ventral pallidum cellular and pathway specificity in drug seeking. Neurosci Biobehav Rev. Dec;131:373-386. doi: 10.1016/j.neubiorev.2021.09.007. Epub 2021 Sep 22.
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Gendelis, S., Inbar, D., Kupchik, Y.M. (2021) The role of nucleus accumbens and ventral pallidum in feeding and obesity. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Jul 6;110394. doi: 10.1016/j.pnpbp.2021.110394.
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Gendelis, S.*, Inbar, D.*, Inbar K., Mesner, S., Kupchik, Y.M. (2020) Metaplasticity in the ventral pallidum as a potential marker for the propensity to gain weight in chronic high-calorie diet. The Journal of Neuroscience, Nov 16:JN-RM-1809-20. doi: 10.1523/JNEUROSCI.1809-20.2020.
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Inbar, K, Levi, L.A., Bernat, N, Odesser, T, Inbar, D., Kupchik Y.M. (2020) Cocaine Dysregulates Dynorphin Modulation of Inhibitory Neurotransmission in the Ventral Pallidum in a Cell-Type-Specific Manner. The Journal of Neuroscience, Feb 5;40(6):1321-1331. doi: 10.1523/JNEUROSCI.1262-19.2019.
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Levi, L.A., Inbar, K., Nachshon, N., Bernat, N., Gatterer, A., Inbar, D., Kupchik, Y.M. (2020) Projection-Specific Potentiation of Ventral Pallidal Glutamatergic Outputs after Abstinence from Cocaine. The Journal of Neuroscience, Feb 5;40(6):1276-1285. doi: 10.1523/JNEUROSCI.0929-19.2019.
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Inbar, D.*, Gendelis, S.*, Mesner, S., Menahem, S., Kupchik, Y.M. (2019) Chronic calorie-dense diet drives differences in motivated food seeking between obesity-prone and resistant mice. Addiction Biology, Apr 22:e12753. doi:10.1111/adb.12753. pdf
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Kupchik, Y.M. and Kalivas P.W. (2017) The direct and indirect pathways of the nucleus accumbens are not what you think. Neuropsychopharmacology, Jan;42(1):369-370. pdf
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Heinsbroek, J.A., Neuhofer, D.N., Griffin III, W.C., Siegel, G.S., Bobadilla, A-C., Kupchik, Y.M.*, Kalivas, P.W.* (2017) Loss of plasticity in D2-accumbens pallidal pathway promotes cocaine seeking. The Journal of Neuroscience, Jan 25;37(4):757-767. (* - equal contribution) pdf
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Scofield, M.D., Heinsbroed, J.A., Gipson, C.D., Kupchik, Y.M., Spencer, S., Smith, A.C.W., Roberts-Wolfe, D., Kalivas, P.W. (2016) The Nucleus Accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis. Pharmacological Reviews, Jul;68(3)816-71. pdf
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Brown, R.M.*, Kupchik, Y.M.*, Spencer, S., Schwartz, D., Garcia-Keller, C., Jordan, K., Jhou, T.C., Kalivas, P.W. (2017) Addiction-like behavior and synaptic plasticity in obesity. Biological Psychiatry. May 1;81(9):797-806. doi: 10.1016/j.biopsych.2015.11.019. (* - equal contribution). pdf
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Garcia-Keller, C., Kupchik, Y.M., Gipson, C.D., Brown, R.M., Spencer, S., Bollati, F., Esparza, M.A., Roberts-Wolfe, D.J., Heinsbroek, J.A., Bobadilla, A.C., Cancela, L.M., and Kalivas, P.W. (2015) Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration. Molecular Psychiatry, DOI: 10.1038/mp.2015.151. pdf
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Kupchik, Y.M., Brown, R.M., Heinsbroek, J.A., Lobo, M.K., Schwartz, D.J., Kalivas, P.W. (2015) Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections. Nature Neuroscience, Sep;18(9):1230-2. pdf
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Stefanik, M.T., Kupchik, Y.M., Kalivas, P.W. (2015) Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior. Brain Structure and Function, 2015 Feb 7. pdf
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Smith, A.W., Kupchik, Y.M., Gipson, C.D., Scofield, M.D., Kalivas, P.W. (2014) Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. Nature Neuroscience, 2014 Dec;17(12):1655-7. pdf
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Spencer, S., Quinteros, G.C., Brown, R.M., Kupchik, Y.M., Thomas, C.A., Reissner, K.J., Kalivas, P.W. (2014) Thrombospondin signaling is necessary for cocaine-induced drug seeking. J. Neuroscience, 34(25):8605-8611. pdf
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Kupchik, Y.M., Scofield, M.D., Rice, K.C., Cheng, K., Roques, B.P., and Kalivas, P.W. (2014) Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum. J. Neuroscience, 34(3):1057-66. pdf
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Gipson, C.D., Kupchik, Y.M., and Kalivas, P.W. (2014) Rapid, transient synaptic plasticity in addiction. Neuropharmacology, 2014 Jan;76 Pt B:276-86. pdf
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Brown, R.M.*, Kupchik, Y.M.*, and Kalivas, P.W. (2013) The story of glutamate in drug addiction and of N-acetylcysteine as a potential pharmacotherapy. JAMA Psychiatry. 2013 Sep;70(9):895-7 (* - equal contribution). pdf
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Stefanik, M.T., Kupchik, Y.M., Brown, R.M., and Kalivas, P.W. (2013) Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking. J. Neuroscience, 33(34):13654-13662. pdf
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Gipson, C.D., Reissner, K.J., Kupchik, Y.M., Smith, A.W., Stankeviciute, N.M., Hensley-Simon, M.E., and Kalivas, P.W. (2013) Rapid synaptic potentiation and glutamate release in nicotine relapse. PNAS, May 28;110(22):9124-9. pdf
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Gipson, C.D.*, Kupchik, Y.M.*, Shen, H.*, Reissner, K.J., Thomas, C.A., and Kalivas, P.W. (2013) Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. Neuron, Mar 6;77(5):867-72. (* - equal contribution). pdf
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Kupchik, Y.M., and Kalivas, P.W. (2012) The rostral subcommissural ventral pallidum is a mix of ventral pallidal neurons and neurons from adjacent areas: an electrophysiological study. Brain Structure and Function, doi: 10.1007/s00429-012-0471-9. pdf
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Stefanik, M., Moussawi, K., Kupchik, Y.M., Smith, K., Miller, R., Huff, M., Deisseroth, K., Kalivas, P.W., and LaLumiere, R. (2013) Optogenetic inhibition of cocaine seeking in rats. Addiction Biology, Jan;18(1):50-3 pdf
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Kupchik, Y.M., Moussawi, K., Tang, X.C., Wang, X., Kalivas, B.C., Kolokithas, R., Ogburn, K.B., and Kalivas, P.W. (2012) The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biological Psychiatry, Jun 1;71(11):978-86. pdf
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Kupchik, Y.M.*, Barchad-Avitzur, O*., Wess, J., Ben-Chaim, Y., Parnas, I., and Parnas, H. (2011) A novel fast mechanism for GPCRs-mediated signal transduction – control of neurotransmitter release. Journal of Cell Biology, 192(1):137-51. (* - equal contribution). pdf
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Kupchik, Y.M., Parnas, H., and Parnas, I. (2011) A novel, extremely fast, feedback inhibition of glutamate release in the crayfish neuromuscular junction. Neuroscience, 172:44-54. pdf
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Kupchik, Y.M., Rashkovan, G., Ohana, L., Keren-Raifman, T., Dascal, N., Parnas, H., and Parnas, I. (2008). Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release. PNAS, 105 (11);4435-4440. pdf